Comminution processes are fundamental operations in raw material processing, they are also the most energy-intensive mining processes. The efficiency improvement of crushing processes is a key problem from technological, economic and ecological points of view. Physico-mechanical feed properties play a key role in the process course optimization, at given technological process conditions. A suitable selection of processing technology for determined ore characteristics increases the process efficiency and the raw materials economy through their better utilization. High-pressure ore comminution processes are practically the most efficient methods of material size reduction. It is a result of the lower process energy-consumption in HPGR and lower energy-consumption of the downstream grinding processes, as compared to conventional crushing devices. The reduction ratio value in downstream upgrading operations is also favourable due to the micro-cracks generation. It appears that the feed particle size distribution during high-pressure comminution is crucial to the obtained technological results. The experimental programme covered investigations of the influence of different particle size composition of ore on technological and economic results as well as the influence of feed moisture content on the process capacity and comminution effects. Economic results were assessed through the HPGR energy-consumption and throughput indices. The results of investigations presented in the paper confirm the thesis that, apart from the dmax value, proportions of individual particle fraction contents are also significant, especially the contents of finer fractions. The crushing results of the material with diverse particle compositions are reflected in the obtained different technological and economic effects. Considering the overall effect it is possible to design the most suitable circuit for a given feed. The results of investigations can be then helpful during the process of industrial application of HPGR, either in modernization of an existing circuit, or during the designing of a new flowsheet. The optimal circuit designed on the basis of crushing results should provide maximization of both technological and economic effects.