Subject of investigations was of copper sulfides such as chalcocite, bornite and chalcopiryte as well as galena. As result of flotation investigations it has been noted that in the presence of copper sulfate all the tested minerals underwent depression though to a different degree depending on the time of flotation, amount of CuSO4 and the time it was supplied - before or after xanthate. In the whole tested range of concentrations (50-300 g/Mg) chalcocite underwent the greatest depression regardless the time of flotation and the way of supplying the reagents. Galena underwent the least depression. Flotability of the remaining sulfides depended, to a considerable degree on the mentioned flotation parameters. Together with the extension of flotation time, flotability of chalcopyrite increased and differences between the flows-off of galena and those of copper sulfides decreased. It can be concluded that the selective separation of the discussed copper sulfides from galena in the presence of copper sulfates will depend considenably on their participation in the feed given to flotation. Results of the elektrocinetic potential dzeta showed that both in distilled water and in the presence of copper sulfate, the tested sulfides showed negative values of the potential.